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Journal of Bacteriology and Virology ; : 152-161, 2014.
Article in English | WPRIM | ID: wpr-163002

ABSTRACT

Oral infection with Porphyromonas (P.) gingivalis causes periodontitis that is manifested by the destruction of gingival connective tissues. Although a few types of antibiotics are effective against the infection, its use induces the appearance of drug-resistant bacteria. The present study shows that the fermented product of Aspergillus (A.) oryzae S-03, cultivated on the fat-removed soybean, inhibits the cell growth of the P. gingivalis. Likewise, the fermented product of the S-03 strain cultured for 26~42 h displays an inhibitory activity to gingipain as a virulence factor of P. gingivalis. The activity is not lost even with heat treatment at 100degrees C for 15 min. We also demonstrate that the S-03 strain exhibits high protease activity. In addition, the strain does not produce aflatoxin because of the loss of a regulatory gene, aflR, necessary for the toxin biosynthesis.


Subject(s)
Aflatoxins , Anti-Bacterial Agents , Aspergillus , Aspergillus oryzae , Bacteria , Connective Tissue , Genes, Regulator , Hot Temperature , Oryza , Periodontitis , Porphyromonas , Porphyromonas gingivalis , Glycine max , Virulence
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